In the last ten years of progress of pharmaceutical industry, a newly arisen high throughput drug screening technology has been widely used in screening precursor of drug by world leading pharmaceutical companies. What we called high throughput drug screening platform is made up of compound library, target selection, developing method for testing reactions between targets and compounds, high throughput technology for screening substances reacting with targets and data processing system. The goal of developing this technology is to find out the best precursor by screening many kinds of synthesized and crude compounds against drug targets and lead the development of new drugs. The advantages of this technology are large scale, high speed, less cost and therefore shorten new drug finding cycle and discover best new medicines.

Crude compound library group 　　Conduct classification and identification of crude materials of Chinese traditional medicine, separate every component by doing primary purification, chromatography and then confirm their chemistry properties, finally enter these data into crude compound library. The crude compound library constructed by this way has the feature of diversified, standardized and systemized. Up to now, we have processed almost 1000 kinds of crude materials of Chinese traditional medicine, constructed crude compound library and established a perfect coordinate database.

Molecular cell biology group
　　Molecular cell biology group is the core of high throughput drug screening platform. The major task of this group is selecting target, developing method for testing reactions between targets and compounds (set up screening model), study of high throughput technology for screening substance reacting with target and data processing system. Up to now, we have following productions:

1. Cloned more than ten drug targets related to some important diseases, including angiocardiopathy, obesity, senility, diabetes and nervous system disease, such as PAFR、 MC4R、serotonin receptors (5HT2c and 5HT7), dopamine receptor，D1 are related to inflammation, senility and nervous system disease respectively. Based on genomics study, we found more than 50 candidates for drug targets, then cloning and validating work are following up.

2. Developed drug target eucaryotic expression system in CHO, HEK/293 and other cell system and did function identification of drug targets.

3. Developed three high specified and highly sensitive systems (CRE/d2EGFP; NFAT/d2EGFP; CRE/NFAT/d2EGFP) for testing cell level to inspect membrane receptor type of target.

4. Developed cell screening model related to MC4R receptor and related to 5HT7 receptor, and is ready for high throughput drug screening.